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KMID : 0387720070180010061
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Korean Journal of Blood Transfusion
2007 Volume.18 No. 1 p.61 ~ p.65
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A Case of D--/D-- Phenotype Associated with Moderate Hemolytic Disease of the Newborn
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Um Tae-Hyun
Cho Chong-Rae
Hwang Jong-Hee
Whang Dong-Hee
Yoon Mi-Sook
Han Kyou-Sup
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Abstract
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The very rare D--/D-- phenotype lacks C, c, E, e antigens with strong expression of the D antigen. A 31-year-old woman delivered her second baby, 3.6 kg girl at 38?4 weeks’ gestation through repeat-Cesarean section. Her parents were not consanguineous. She had one artificial abortion, one Cesarean section with red blood cell transfusion and two spontaneous abortions. Her red cells were typed as O, D?C-c-E-e- and did not react with anti-Hro (Rh 17). Her serum reacted with all of the screening cells and identification panel cells with strength of (??)∼(???). The baby was mildly jaundiced 12 hours after delivery. At 1 day after delivery, total bilirubin was 17.7 mg/dL, and direct and indirect antiglobulin tests were both positive. Phototherapy was immediately given for the baby but jaundice and anemia were worsened. Twenty six milliliter of the mother’s whole blood was given twice to the baby after plasma depletion and leukocyte reduction. The baby showed improvement of jaundice and anemia, and discharged at hospital day 14. As far as we know, this is the third reported case of hemolytic disease of the newborn occurred in the D--/D-- mother with anti-Hro in Korea, and the first case that was neither fatal nor treated with intensive medical care.
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KEYWORD
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D--/D-- phenotype, Hemolytic disease of the newborn (HDN), Anti-Hro
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